Genetic tumor diagnostics provides the information basis for treatment decisions
Cancer arises from changes in genes that deregulate cell growth and cause cells to grow out of control. Genetic tumor diagnostics hence is a powerful tumor diagnostic tool as it detects predispositions for cancer, identifies existing diseases and gives insights into the disease mechanism for optimal treatment decisions.
A valid diagnosis improves the patient’s quality of life drastically. It provides clarity and guidelines for action to lower the risk of developing cancer or to detect the disease early. Based on the information gained, physicians who treat patients with cancer can determine the most effective therapy to increase the chances of recovery.
Genetic diagnostics should be integrated early into the diagnostic plan – because the right diagnosis is the basis for optimal management of cancer.
Process for diagnostics
Step 1:
Test selection. We are happy to assist in choosing the suitable diagnostic strategy
Step 2:
Counseling. Patient receives genetic counseling and signs the order and consent form. Patient samples are retrieved and together with the order form send to CeGaT.
Step 3:
Analysis. CeGaT performs the requested analysis and issues medical report.
Step 4:
Counseling. Results are discussed with the patient.
Step 5:
Implementation. The results obtained from genetic testing are integrated in patient care.
CancerPrecision
Comprehensive Diagnostics for targeted cancer treatment
The Somatic Tumor Diagnostics Panel characterizes the molecular changes within the tumor. The identification of genetic variants helps to determine promising therapeutic strategies and avoid ineffective treatments, considerably increasing the chances of treatment success.
CancerNeo
Identify neoantigens for personalized cancer vaccine design
Tumor immunotherapy diagnostics supports the design of cancer vaccines that boost the immune system’s response against cancer cells. The combination of whole-exome and transcriptome sequencing with MHC-classification identifies neoantigens, the base for patient-individualized cancer vaccine approaches.
CancerEssential
Evaluate the suitability of planned therapies for the most common tumor entities
This cost-saving and focused analysis of selected therapy-relevant genes supports therapy decision-making. The Molecular Pathology Panel detects the most important driver mutations within the most common tumor entities.
Family risk assessment and prevention
Genetic tumor diagnostics clarifies cancer predispositions and allows for early action
Every fifth tumor develops due to a hereditary predisposition. Prevention is the most important measure in the fight against tumor diseases. Knowing predispositions and initiating appropriate early detection examinations are central components in preventing metastatic and late-detected disease progression. Genetic tumor diagnosis is especially important for persons with a family history of cancer as it assesses their risk of developing cancer.
Diagnostic Panel for Hereditary Tumor Diseases
Detect hereditary predispositions to cancer
The Diagnostic Panel for Hereditary Tumor Diseases is tailored for families with increased cancer risk. It detects predispositions early on, which gives valuable time to initiate preventive measures and medical checkups. Cancer can thus be detected at an early stage when it is best treatable.
Disease Prevention Panel
Understand genetic risk factors and plan health care
The Prevention Panel detects genetic risk factors for different diseases, including tumor diseases. Measures can be taken to lower the risk to develop cancer and to detect tumoras at an early stage.
About Tumor Development
Tumors develop from cells as a consequence of changes in genes, called mutations. These changes happen by chance and normally are corrected by the cell’s DNA repair systems. Exposure to carcinogens, such as tobacco smoke or UV radiation, increases the number of mutations. A not correctly repaired mutation can lead to cancer. These obtained mutations are called somatic mutations. Cancer promoting somatic mutations result in changed protein functions leading to dysregulated cellular processes. Initially, these genetic changes promote loss of growth control in affected cells during cell division. Additional mutations select for cell clones which successfully continue proliferation and decrease their rate of death. Further mutations accumulate in the course of tumor progression and promote tumor cell distribution to distant organs (metastases). The somatic mutations which are acquired by tumors in the course of the disease are individual and differ not only between different cancer entities but also from patient to patient. Thus, cancer is a multifactorial and heterogeneous genetic disease.
Every tumor is unique.
The individual set of tumor-specific mutations helps the tumor to survive, reduce sensitivity to treatment, and develop resistance against therapeutic agents. Knowing the somatic mutations helps to identify promising therapeutic strategies and to avoid ineffective treatment options with their associated side effects. Currently, anti-cancer therapies are still mostly chosen based upon the organ of origin. However, studies show that comprehensive genetic tumor diagnostics provide therapeutically relevant information in over 76% of all tested cases (Frampton et al., 2013; CeGaT internal data).
Tumor progression
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Our dedicated support assists you in choosing the most appropriate diagnostic test for your patients.
