The Human Leucocyte Antigen (HLA) system is a group of genes encoding proteins that determine the human specific immune response. This region is highly polymorphic and contains six classical genes: class I HLA-A, -B and -C, and class II HLA-DRB1, -DQB1 and -DPB1. Furthermore, the HLA region is known to be associated with more than 100 multifactorial, complex diseases mainly of inflammatory and autoimmune pathogenesis.
In order to find out more about the functions and complex interactions of the HLA system, next-generation sequencing (NGS) based HLA typing can be very helpful. For instance, it can identify HLA-matched donor-recipient pairs for transplantation, facilitate individual therapy response using pharmacogenetics, or provide information on specific responses for immunotherapy of cancer.
CeGaT offers two HLA typing options: