Peripheral PD-1+CD56+ T-cell frequencies correlate with outcome in stage IV melanoma under PD-1 blockade

Bochem J1, Zelba H1,Amaral T1,2, Spreuer J1, Soffel D1, Eigentler T1, Wagner NB1, Uslu U3, Terheyden P4, Meier F5,6, Garbe C1, Pawelec G7,8,9,10,11, Weide B1, Wistuba-Hamprecht K1.
  1. Department of Dermatology, University Medical Center, Tübingen, Germany.
  2. Portuguese Air Force Health Direction, Lisbon, Portugal.
  3. Department of Dermatology, Friedrich-Alexander-University of Erlangen-Nürnberg (FAU), Universitätsklinikum Erlangen, Erlangen, Germany.
  4. Department of Dermatology, University of Lübeck, Lübeck, Germany.
  5. Skin Cancer Center at the University Cancer Centre, Department of Dermatology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
  6. National Center for Tumor Diseases (NCT), Dresden, and German Cancer Research Center (DKFZ), Heidelberg, Germany.
  7. Department of Immunology, University of Tübingen, Tübingen, Germany.
  8. Health Sciences North Research Institute, Sudbury, Ontario, Canada.
  9. Division of Cancer Studies, King’s College London, London, United Kingdom.
  10. John van Geest Cancer Research Centre, Nottingham Trent University, Nottingham, United Kingdom.
  11. Institute of Cancer Sciences, Manchester University, Manchester, United Kingdom.