CeGaT, JSW Lifesciences GmbH, Grambach, Austria, and NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen, Reutlingen, Germany, today announced that they will develop novel models for Alzheimer’s and related diseases based on the mitochondrial cascade hypothesis.
Within the three year project, knocking-down of mitochondrial proteins will be used to elucidate the specific involvement of mitochondria in neuron homeostasis and synaptic connectivity in cell culture as well as in newly developed animal models. Mitochondria are crucial for the survival and death of neurons and high energy-dependent cell types, in general. Changes in mitochondrial membrane potential, membrane composition, protein import, respiratory chain, ATP production, fission, fusion, transport and degradation of mitochondria will ultimately affect central functions of individual cells, especially in the mammalian brain. Using next generation high throughput sequencing technology, early and late changes affecting mitochondria in newly developed cell culture and animal models will be analysed in depth.
By utilizing this approach novel drug targets for neurodegenerative diseases like Alzheimer and Parkinson will be developed with potential broad application in clinical use.
The consortium consists of one contract research organisation (JSW), one research institute with broad experience in the identification and validation of drug targets (NMI) and one sequencing enterprise able to apply cutting edge sequencing technology and knowledge in bioinformatics to effectively process data obtained (CeGaT). This unique composition of expertise and infrastructure will guarantee a successful performance of the project.
About JSW Lifesciences GmbH
JSW is a preclinical and clinical contract research organisation founded in 1999. In preclinical research the enterprise focuses on disorders affecting the central nervous system (CNS) and developed profound expertise with a variety of genetically modified rat and mouse disease models for CNS disorders. More information: www.jsw-lifesciences.com.
About NMI Natural and Medical Sciences Institute at the University of Tübingen, Reutlingen
The NMI is an application-oriented research institute that makes the results of scientific study available to industry. The interdisciplinary approach of the NMI includes basic research as well as practical problem solving in the form of applied research and development, consultancy, testing, measuring and analysis, scientific studies, and implementation in the fields of pharma- and biotechnology, biomedical technology as well as surface and interface technologies. The NMI makes use of interdisciplinary know-how, modern equipment, quality management processes and a network of companies including various branches of industry, in particular the life sciences. More information: www.nmi.de.