CeGaT upgrades its Epilepsy Panel

Based on the latest research further genes have been added to the existing Epilepsy panel. Furthermore we have introduced 6 new subpanels.
We are now offering 20 Epilepsy subpanels with in total 327 genes:

  • Epilepsy Subpanel 1: Generalized / Myoclonic Epilepsy, Febrile Seizures, Absences (now 38 genes)
  • Epilepsy Subpanel 2: Epileptic Encephalopathies (now 30 genes)
  • Epilepsy Subpanel 3: Epilepsy and X-linked Mental Retardation (now 25 genes)
  • Epilepsy Subpanel 4: CDG (Congenital Disorder of Glycosylation) Syndrome (now 23 genes)
  • Epilepsy Subpanel 5: Ceroidlipofuscinosis (now 8 genes)
  • Epilepsy Subpanel 6: Coenzyme Q Deficiency Syndrome (now 5 genes)
  • Epilepsy Subpanel 7: Joubert Syndrome (now 10 genes)
  • Epilepsy Subpanel 8: Selected Mitochondrial Disorders (now 35 nuclear encoded genes)
  • Epilepsy Subpanel 9: Lissencephaly and Polymicrogyria (now 18 genes)
  • Epilepsy Subpanel 10: Microcephaly and Pontocerebellar Hypoplasia (now 22 genes)
  • Epilepsy Subpanel 11: MPS and Mucolipidosis (now 15 genes)
  • new: Epilepsy Subpanel 12: Disorders of the Ras-MAPK Pathway (14 genes)
  • Epilepsy Subpanel 13: Walker-Warburg Syndrome (now 6 genes)
  • Epilepsy Subpanel 14: Zellweger Syndrome (now 9 genes)
  • Epilepsy Subpanel 15: Metabolic Disorders (now 50 genes)
  • new: Epilepsy Subpanel 16: Leukodystrophies (20 genes)
  • new: Epilepsy Subpanel 17: Migraine (6 genes)
  • new: Epilepsy Subpanel 18: Hyperekplexia (5 genes)
  • new: Epilepsy Subpanel 19: Holoprosencephaly (8 genes)
  • new: Epilepsy Subpanel 20: Neuronal Migration Disorders (31 genes)

For further information please visit our Epilepsy Panel section.

CeGaT, JSW, and NMI work on novel Alzheimer’s Disease Models

CeGaT, JSW Lifesciences GmbH, Grambach, Austria, and NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen, Reutlingen, Germany, today announced that they will develop novel models for Alzheimer’s and related diseases based on the mitochondrial cascade hypothesis.

Within the three year project, knocking-down of mitochondrial proteins will be used to elucidate the specific involvement of mitochondria in neuron homeostasis and synaptic connectivity in cell culture as well as in newly developed animal models. Mitochondria are crucial for the survival and death of neurons and high energy-dependent cell types, in general. Changes in mitochondrial membrane potential, membrane composition, protein import, respiratory chain, ATP production, fission, fusion, transport and degradation of mitochondria will ultimately affect central functions of individual cells, especially in the mammalian brain. Using next generation high throughput sequencing technology, early and late changes affecting mitochondria in newly developed cell culture and animal models will be analysed in depth.
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New Retina subpanels

CeGaT introduces three additional Subpanels for Hereditary Eye Diseases:

  • Stargardt disease and macular dystrophies (11 Genes)
  • Cone rod dystrophies (25 Genes)
  • Flecked retina disorders (6 Genes)

We are now offering 32 Subpanels:

  • Dementia and ALS (1 Subpanel – 20 Genes)
  • Parkinson Syndrome (1 Subpanel – 16 Genes)
  • Epilepsy (15 Subpanels – 265 Genes)
  • Hereditary Eye Diseases (15 Subpanels – 196 Genes)

For further information please visit our Diagnostic Panels section.

New Epilepsy subpanels

CeGaT introduced 15 Epilepsy Subpanels. With these Diagnostic Panels all genes associated with Epilepsy can be sequenced simultaneously on our SOLiD 4 platform. We offer a full Epilepsy Diagnostic (Sequencing on SOLiD 4 system, Data Analysis, Re-Sequencing of Variants, Report) for each of our subpanels.

We are now offering 28 subpanels:

  • Dementia and ALS (1 Panel – 20 genes)
  • Parkinson Syndrome (1 Panel – 16 genes)
  • Epilepsy (15 Panels – 265 genes)
  • Hereditary Eye Diseases (11 Panels – 168 genes)

For further information please visit the Diagnostic Panels section.

Introduction of Diagnostic Panels

CeGaT is among the worldwide pioneers and the first German company introducing Diagnostic Panels.
With our panels a high number of genes can be sequenced and diagnosed simultaneously. In total we offer 16 different subpanels:

  • Dementia and ALS (1 Subpanel, 20 Genes)
  • Parkinson Syndrome (1 Subpanel, 16 Genes)
  • Epilepsy (3 Subpanels – 55 Genes)
  • Hereditary Eye Diseases (11 Subpanels, 150 Genes)

For further information please visit the Diagnostic Panels section.