CeGaT, JSW Lifesciences GmbH, Grambach, Austria, and NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen, Reutlingen, Germany, today announced that they will develop novel models for Alzheimer’s and related diseases based on the mitochondrial cascade hypothesis.
Within the three year project, knocking-down of mitochondrial proteins will be used to elucidate the specific involvement of mitochondria in neuron homeostasis and synaptic connectivity in cell culture as well as in newly developed animal models. Mitochondria are crucial for the survival and death of neurons and high energy-dependent cell types, in general. Changes in mitochondrial membrane potential, membrane composition, protein import, respiratory chain, ATP production, fission, fusion, transport and degradation of mitochondria will ultimately affect central functions of individual cells, especially in the mammalian brain. Using next generation high throughput sequencing technology, early and late changes affecting mitochondria in newly developed cell culture and animal models will be analysed in depth.