CeGaT Tests for Active Corona Infections

Since October 1, anyone who would like to (or has to) be tested for active corona infections can come to CeGaT’s premises without prior appointment. The result is available within 24 hours and can be downloaded via a secure system. For companies and larger groups, CeGaT offers a mobile service for taking nasopharyngeal swabs. In […]

Update and Extension of the Panel for Genetic Eye Diseases

CeGaT has updated and expanded the Diagnostic Panel for Genetic Eye Diseases. As part of the regular updates, the panel was revised according to the current scientific knowledge, thereby increasing its diagnostic sensitivity.

In addition, new gene sets have been added to the panel, which can now also be used for precise diagnoses of the following hereditary eye diseases:

Congenital nystagmus, X-linked

Congenital nystagmus is characterized by congenital, uncontrolled movements of the eyes, which are also described as jerking or trembling. Eye movement disorders vary greatly in frequency, amplitude, and shape (e.g., pendulum nystagmus) and are sometimes accompanied by visual impairment and disturbances. The X-linked nystagmus usually occurs in the first half-year of life and results from changes in the genes FRMD7 and GPR143.

Progressive external ophthalmoplegia

Progressive external ophthalmoplegia manifests in progressive paralysis of the external eye muscles, which severely limits the movement of the eyes. Since eyelid muscles can also be affected, a common sign of the disease is the drooping of one or both eyelids (ptosis). The cause are mitochondriopathies, which are caused by a malfunction or damage to the mitochondria.

Congenital cranial dysinnervation syndromes

Congenital cranial dysinnervation syndromes (CCDDs) are a subgroup of incomitant strabismus. It describes strabismus syndromes in which the degree of strabismus depends on the direction of gaze. It is characterized by a non-progressive disturbance of the eye movement (oculomotor function), in some cases accompanied by upper eyelid ptosis, i.e. the drooping of an eyelid. The syndromes are caused by diseases or maldevelopments of eye muscles or eye cavities (orbital diseases) or cranial nerves (cranial nerve paresis). They cause a defective innervation of the muscles.

All CeGaT panels are examined with CeGaT’s large panel approach. We always sequence all genes of a panel and evaluate the requested gene set. If necessary, we can quickly extend the evaluation to other gene sets. This gives you access to the most flexible and cost-efficient differential diagnostics. In addition, we offer a screening of all differential diagnostic relevant genes of the panel for variants of ACMG classes 4 and 5. CeGaT’s panel diagnostics also include the free of charge regular re-evaluation of variants of uncertain clinical significance (VUS) to increase the diagnostic yield further.

We are convinced that all patients should receive the best possible diagnostics. For this reason, our panels routinely examine single nucleotide variation (SNVs) and copy number variants (CNVs) and check for mosaicism. If necessary, we validate pathogenic deletions or duplications using MLPA or qPCR before reporting. The highest quality is our standard.

For further information on the panels, please contact us at sales@cegat.com. The new panel can be ordered here.

Frequently Asked Questions about the Corona Test Center at Stuttgart Airport

My sample was taken before August 13th, 2020. Can I ask you for more information?
We have only been operating the test center at Stuttgart Airport since August 13, 2020. We cannot provide any information about medical reports that were issued before that date.

Can I get my results by email?
No. For data protection reasons, we are not allowed to send any medical reports by email. You can receive your result via the Corona Warning App or by contacting our hotline under 07071 5654420 (available Monday – Friday  9:00 a.m. – 16:00 p.m.). Each tested person receives the result by mail to the address stated at the airport.

How long will it take to get a result?
Up to 3 days.

Will my result be reported to the public health department?
All positive findings will be reported to the public health department.

Can I have a test carried out at the airport if I am not arriving by plane?
All travelers returning from abroad can be tested. However, we need verification (hotel bill, train ticket etc.) that you have stayed abroad.

When can I get tested?
The test center is open daily from 6:00 a.m. to 11:00 p.m.

Praxis für Humangenetik Tübingen, Airport Medical Center und CeGaT führen Corona-Akutdiagnostik am Flughafen Stuttgart durch

Seit heute sind die Praxis für Humangenetik Tübingen, Dr. Dr. Saskia Biskup, in enger Zusammenarbeit mit dem Airport Medical Center MVZ, Dr. Jens Künzel, und der CeGaT GmbH im Corona-Testzentrum am Stuttgarter Flughafen tätig.

Das Testzentrum bietet seit Anfang August Tests zum Direktnachweis des neuartigen Coronavirus an. Passagiere erfahren durch den Test schnell und zuverlässig, ob sie mit SARS-CoV-2 infiziert sind. Wir unterstützen damit gemeinsam die Bemühungen, die Verbreitung von COVID-19 einzudämmen und erfüllen den entsprechenden Versorgungsauftrag.

Für den Test werden Abstriche aus dem Nasen-Rachen-Raum mittels Real-Time-Polymerasekettenreaktion (RT-PCR) auf virale RNA hin untersucht. Die in der Teststation am Flughafen Stuttgart entnommenen Proben werden in dem Tübinger Labor der CeGaT untersucht. Die Testergebnisse liegen am nächsten Tag vor und werden per Post versandt.
Für Rückkehrende aus Risikogebieten ist der Test seit Anfang August verpflichtend. Die Teststation befindet sich in Terminal 1 und ist täglich von 6:00 Uhr bis 23:00 Uhr geöffnet.

Wir danken dem Airport Medical Center MVZ, dem Stuttgarter Flughafen, der Kassenärztlichen Vereinigung Baden-Württemberg und dem Sozialministerium für die reibungslose Zusammenarbeit, ohne die die schnelle Integration in die Corona-Teststation am Flughafen Stuttgart nicht möglich gewesen wäre.

CeGaT Offers Corona Antibody Test

Since May 11, 2020, CeGaT offers a CE certified corona antibody test. This test determines whether a person has antibodies against the coronavirus SARS-CoV-2. People who have antibodies are assumed to have undergone a coronavirus infection and are highly likely to be immune.

The collection tubes required for the test can be ordered via the web portal www.cegat.com/corona. Also, the free-of-charge blood collection has started on the premises of CeGaT (open Mon-Fri 8 am – 6 pm).
Corona antibody test

  • CE certified test for antibodies directed against the S1 domain of the spike protein of SARS-CoV-2
  • Required sample material: blood (serum)
  • Price per test: EUR 25,- (incl. VAT)
  • Blood collection tubes can be ordered (free of charge) via our web portal. These CeGaT tubes are mandatory; other blood collection tubes cannot be accepted for technical reasons.
  • Blood collection is also possible on the CeGaT premises (Mon-Fri 8 am -6 pm, no appointment necessary). In this case, CeGaT tubes do not have to be ordered in advance. The blood collection is free of charge.
  • Information on the test is also available online at cegat.com/corona.
  • A team is now available to answer your questions at corona@cegat.com or +49 7071 5654420. 

The current state of knowledge on immunity after a past infection

The chances of immunity against SARS-CoV-2 after recovery from COVID-19 are very high. In a recent study, published in the peer-reviewed journal Cell, 13 of 14 patients that recovered from COVID-19 showed antibodies against the spike protein of the novel coronavirus. The sera of these 13 patients showed anti-viral effects in so-called neutralization assays. This type of cellular assay is considered to be the secure proof that the patients’ antibodies can neutralize the novel coronavirus. The original publication can be found here: https://www.cell.com/immunity/pdf/S1074-7613(20)30181-3.pdf

The specificity of our corona antibody test

CeGaT uses a test procedure developed together with the Reutlingen-based biotechnology company Mediagnost. It detects IgG antibodies directed against the S1 domain of the SARS CoV-2 spike protein. This approach provides the best possible specificity for tests for the novel coronavirus (SARS-CoV-2) – as also used e.g. in the Euroimmun test. The Mediagnost assay received CE certification last week.

The data submitted for CE-marking show a sensitivity of >95% and a specificity of almost 99% for the test, based on a cohort size of almost 300 patients. The sensitivity of the test is expected to increase with a longer time interval between disease and conducting the test (3-4 weeks).

Our test provides significantly higher specificity than the rapid antibody tests available today (these have a specificity of only 60-70%). Its specificity is also higher than the specificity of antibody tests that aim to detect antibodies against the protein nucleocapsid: The nucleocapsid protein shows higher similarity to other more harmless corona cold viruses than the S1 domain of the spike protein of SARS-CoV-2. The more similar the protein to be detected is to proteins of closely related viruses, the higher the probability of false-positive results.

We are convinced that with our antibody test, we are offering you a high-quality test that is at the same time inexpensive, very fast, and also available in high-throughput. As always, quality is our top priority.