Clinical and Genetic Tumor Characteristics of Responding and Non-Responding Patients to PD-1 Inhibition in Hepatocellular Carcinoma

Stephan Spahn 1, Daniel Roessler 2, Radu Pompilia 3 4, Gisela Gabernet 5, Beryl Primrose Gladstone 1, Marius Horger 6, Saskia Biskup 7, Magdalena Feldhahn 7 , Sven Nahnsen 5, Franz J Hilke 8 9, Bernhard Scheiner 10, Jean-François Dufour 3 4, Enrico N De Toni 2, Matthias Pinter 10, Nisar P Malek 1 11, Michael Bitzer 1 11
  1. Department Internal Medicine I, Eberhard-Karls University, 72076 Tuebingen, Germany.
  2. Department of Medicine II, University Hospital Ludwig-Maximilians-University (LMU), 81377 Munich, Germany.
  3. Hepatology-Department of Biomedical Research, University of Bern, 3010 Bern, Switzerland.
  4. University Clinic for Visceral Surgery and Medicine, Inselspital, University of Bern, 3010 Bern, Switzerland.
  5. Quantitative Biology Center (QBiC), Eberhard-Karls University, 72076 Tuebingen, Germany.
  6. Department of Diagnostic and Interventional Radiology, Eberhard-Karls University, 72076 Tuebingen, Germany.
  7. CeGaT GmbH and Praxis für Humangenetik, 72076 Tuebingen, Germany.
  8. Institute of Medical Genetics and Applied Genomics, Eberhard-Karls University, 72076 Tuebingen, Germany.
  9. Department of Dermatology, Venerology and Allergology, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.
  10. Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, 1090 Vienna, Austria.
  11. Center for Personalized Medicine, Eberhard-Karls University, 72076 Tuebingen, Germany.