Cancer immune control needs senescence induction by interferon-dependent cell cycle regulator pathways in tumours.

Authors

Brenner E1, Schörg BF2, Ahmetlić F3,4, Wieder T1, Hilke FJ5, Simon N1, Schroeder C5, Demidov G5, Riedel T3, Fehrenbacher B1, Schaller M1, Forschner A1, Eigentler T1, Niessner H1, Sinnberg T1, Böhm KS1, Hömberg N3,4, Braumüller H1, Dauch D6,7, Zwirner S6, Zender L6,7,8, Sonanini D2,6, Geishauser A34, Bauer J1, Eichner M9, Jarick KJ10, Beilhack A10, Biskup S8,11, Döcker D1,11, Schadendorf D7,12, Quintanilla-Martinez L8,13, Pichler BJ2,8, Kneilling M1,2,8, Mocikat R3,4, Röcken M14,15,16.
  1. Department of Dermatology, University of Tübingen, 72076, Tübingen, Germany.
  2. Department of Preclinical Imaging and Radiopharmacy, Laboratory for Preclinical Imaging and Imaging Technology of the Werner Siemens-Foundation, University of Tübingen, 72076, Tübingen, Germany.
  3. Institut für Molekulare Immunologie, Helmholtz-Zentrum München, 81377, Munich, Germany.
  4. Eigenständige Forschungseinheit Translationale Molekulare Immunologie, Helmholtz Zentrum München, 81377, Munich, Germany.
  5. Institute of Medical Genetics and Applied Genomics, University of Tübingen, 72076, Tübingen, Germany.
  6. Department of Medical Oncology and Pneumology, University Hospital Tübingen, 72076, Tübingen, Germany.
  7. German Cancer Research Consortium (DKTK), German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany.
  8. Cluster of Excellence iFIT (EXC 2180) „Image Guided and Functionally Instructed Tumor Therapies“, 72076, Tübingen, Germany.
  9. Institute of Clinical Epidemiology and Applied Biometry, University of Tübingen, 72076, Tübingen, Germany.
  10. Department of Medicine II, Würzburg University, 97078, Würzburg, Germany.
  11. Center for Genomics and Transcriptomics (CeGaT) GmbH and Practice for Human Genetics, 72076, Tübingen, Germany.
  12. Department of Dermatology, University Hospital, West German Cancer Centre, University Duisburg-Essen, 45147, Essen, Germany.
  13. Institute of Pathology, University of Tübingen, 72076, Tübingen, Germany.
  14. Department of Dermatology, University of Tübingen, 72076, Tübingen, Germany. mrocken@med.uni-tuebingen.de.
  15. German Cancer Research Consortium (DKTK), German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany. mrocken@med.uni-tuebingen.de.
  16. Cluster of Excellence iFIT (EXC 2180) „Image Guided and Functionally Instructed Tumor Therapies“, 72076, Tübingen, Germany. mrocken@med.uni-tuebingen.de.