CeGaT Panel for Hearing Loss

Information

The panel for hereditary Hearing Loss covers 126 genes. All of these genes are sequenced simultaneously. Only genes which have an association with the phenotype of the patient will be interpreted. Below, next to all genes of the panel, you can find our proposed gene sets.

For diagnostic purposes, each of the gene sets can be requested individually or in combination. A combination of individual genes is also possible.

For questions please do not hesitate to contact our Diagnostic Support team.

Method

The enrichment of the coding regions and the adjacent intronic regions is performed using the in-Solution Agilent technology (SureSelectXT). The selection of the targeted regions and the design of the enrichment baits is performed in-house.

High throughput sequencing is performed on the Illumina HiSeq Platform.
Bioinformatic processing of the data is achieved using an in-house computer cluster.

Following data processing, our team of scientists and specialists in human genetics analyze the data and issue a medical report.

Material and turnaround time
  • 3-5 ml EDTA-Blood or 5 µg genomic DNA
  • Order form with declaration of consent according to German Gendiagnostikgesetz (GenDG)

Turnaround time: 4-6 weeks

Hearing Loss, nonsyndromic, autosomal recessive and X-linked (53 Genes, EAR01)

CABP2, CDH23, CIB2, CLDN14, CLIC5, COL11A2, COL4A6, DFNB31, DFNB59, ESPN, ESRRB, GIPC3, GJB2, GJB3, GJB6, GPSM2, GRXCR1, HGF, ILDR1, KARS, LHFPL5, LOXHD1, LRTOMT, MARVELD2, MSRB3, MYO15A, MYO3A, MYO6, MYO7A, OTOA, OTOF, OTOG, OTOGL, PCDH15, POU3F4, PRPS1, PTPRQ, RDX, SERPINB6, SLC26A4, SLC26A5, SLITRK6, SMPX, STRC, TECTA, TMC1, TMC2, TMIE, TMPRSS3, TPRN, TRIOBP, TSPEAR, USH1C

Order form

Hearing Loss, nonsyndromic, autosomal dominant and X-linked (35 Genes, EAR02)

ACTG1, CCDC50, CEACAM16, COCH, COL11A2, COL4A6, CRYM, DFNA5, DIABLO, DIAPH1, DIAPH3, DSPP, EYA4, GJB2, GJB3, GJB6, GRHL2, KCNQ4, MIR96, MYH14, MYH9, MYO1A, MYO6, MYO7A, POU3F4, POU4F3, PRPS1, SLC17A8, SMPX, TECTA, TJP2, TMC1, TMC2, TNC, WFS1

Order form

Syndromic Hearing Loss (62 Genes, EAR03)

ABHD12, ALMS1, ANKH, ATP6V1B1, BSND, CACNA1D, CD151, CDH23, CDKN1C, CHD7, CHSY1, CIB2, CLRN1, COL11A1, COL11A2, COL2A1, COL4A3, COL4A4, COL4A5, COL4A6, COL9A1, COL9A2, COL9A3, DFNB31, DLX5, EDN3, EDNRB, EYA1, FGF3, FOXI1, GATA3, GPR98, HOXB1, KCNE1, KCNJ10, KCNQ1, MANBA, MITF, MYO7A, NDP, NLRP3, PAX3, PCDH15, PDZD7, POLR1C, POLR1D, SEMA3E, SIX1, SIX5, SLC19A2, SLC26A4, SLITRK6, SNAI2, SOX10, TCOF1, TFAP2A, TIMM8A, TYR, USH1C, USH1G, USH2A, WFS1

Order form

Complete Panel - Hearing Loss (126 Genes)

ABHD12, ACTG1, ALMS1, ANKH, ATP6V1B1, BSND, CABP2, CACNA1D, CCDC50, CD151, CDH23, CDKN1C, CEACAM16, CHD7, CHSY1, CIB2, CLDN14, CLIC5, CLRN1, COCH, COL11A1, COL11A2, COL2A1, COL4A3, COL4A4, COL4A5, COL4A6, COL9A1, COL9A2, COL9A3, CRYM, DFNA5, DFNB31, DFNB59, DIABLO, DIAPH1, DIAPH3, DLX5, DSPP, EDN3, EDNRB, ESPN, ESRRB, EYA1, EYA4, FGF3, FOXI1, GATA3, GIPC3, GJB2, GJB3, GJB6, GPR98, GPSM2, GRHL2, GRXCR1, HGF, HOXB1, ILDR1, KARS, KCNE1, KCNJ10, KCNQ1, KCNQ4, LHFPL5, LOXHD1, LRTOMT, MANBA, MARVELD2, MIR96, MITF, MSRB3, MYH14, MYH9, MYO15A, MYO1A, MYO3A, MYO6, MYO7A, NDP, NLRP3, OTOA, OTOF, OTOG, OTOGL, PAX3, PCDH15, PDZD7, POLR1C, POLR1D, POU3F4, POU4F3, PRPS1, PTPRQ, RDX, SEMA3E, SERPINB6, SIX1, SIX5, SLC17A8, SLC19A2, SLC26A4, SLC26A5, SLITRK6, SMPX, SNAI2, SOX10, STRC, TCOF1, TECTA, TFAP2A, TIMM8A, TJP2, TMC1, TMC2, TMIE, TMPRSS3, TNC, TPRN, TRIOBP, TSPEAR, TYR, USH1C, USH1G, USH2A, WFS1

Order form