CeGaT Panel for Epilepsy, Metabolic and Brain Development Disorders

Information

The panel for hereditary Epilepsy, Metabolic and Brain Development Disorders covers 634 genes. All of these genes are sequenced simultaneously. Only genes which have an association with the phenotype of the patient will be interpreted. Below, next to all genes of the panel, you can find our proposed gene sets.

For diagnostic purposes, each of the gene sets can be requested individually or in combination. A combination of individual genes is also possible.

Should you have any questions please do not hesitate to contact our Diagnostic Support team.

Method

The enrichment of the coding regions and the adjacent intronic regions is performed using the in-Solution Agilent technology (SureSelectXT). The selection of the targeted regions and the design of the enrichment baits is performed in-house.

High throughput sequencing is performed on the Illumina HiSeq Platform.
Bioinformatic processing of the data is achieved using an in-house computer cluster.

Following data processing, our team of scientists and specialists in human genetics analyze the data and issue a medical report.

Material and turnaround time
  • 3-5 ml EDTA-Blood or 5 µg genomic DNA
  • Order form with declaration of consent according to German Gendiagnostikgesetz (GenDG)

Turnaround time: 4-6 weeks

Epilepsy

Familial and Idiopathic Epilepsy (29 Genes, EPI01)

ADRA2B, ALDH7A1, CACNA1A, CHRNA4, CHRNB2, CNTN2, DEPDC5, GABRA1, GABRB3, GABRG2, GRIN2A, KCNA1, KCNMA1, KCNQ2, KCNQ3, KCNT1, LGI1, NPRL2, NPRL3, PRRT2, RELN, SCN1A, SCN1B, SCN2A, SCN8A, SLC1A3, SLC2A1, STX1B, TBC1D24

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Epilepsy and Developmental Delay (incl. Epileptic Encephalopathies) (78 Genes, EPI02)

AARS, ALDH7A1, ALG13, AMT, ARHGEF9, ARX, BRAT1, CACNA1A, CASK, CDKL5, CHD2, CNNM2, DNM1, DOCK7, EEF1A2, FOXG1, GABRA1, GABRB3, GAMT, GLDC, GNAO1, GNB1, GPHN, GRIN1, GRIN2A, GRIN2B, GRIN2D, HACE1, HCN1, HNRNPU, IQSEC2, ITPA, KCNA2, KCNB1, KCNQ2, KCNT1, MBD5, MECP2, MEF2C, MOCS1, MOCS2, NECAP1, PCDH19, PIGA, PLCB1, PNKP, PNPO, POLG, PURA, QARS, ROGDI, SCN1A, SCN2A, SCN8A, SIK1, SLC12A5, SLC13A5, SLC25A22, SLC2A1, SLC35A2, SLC6A1, SLC6A8, SLC9A6, SMC1A, SPTAN1, ST3GAL3, ST3GAL5, STXBP1, SYNGAP1, SZT2, TBC1D24, TCF4, TSC1, TSC2, UBE3A, WDR45, WWOX, ZEB2

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Neuronal Ceroid Lipofuscinosis and Progressive Myoclonus Epilepsy (28 Genes, EPI05)

AFG3L2, ASAH1, ATP13A2, CARS2, CERS1, CLN3, CLN5, CLN6, CLN8, CSTB, CTSD, CTSF, DNAJC5, EPM2A, GOSR2, GRN, KCNC1, KCTD7, LMNB2, MFSD8, NEU1, NHLRC1, PPT1, PRDM8, PRICKLE1, SCARB2, SERPINI1, TPP1

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GPI anchor deficiency with or without Hyperphosphatasia (12 Genes, EPI12)

PGAP2, PGAP3, PIGA, PIGG, PIGL, PIGM, PIGN, PIGO, PIGT, PIGV, PIGW, PIGY

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Migraine (9 Genes, EPI14)

ATP1A2, ATP1A3, CACNA1A, NOTCH3, POLG, PRRT2, SCN1A, SLC1A3, SLC2A1

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Hyperekplexia (3 Genes, EPI15)

GLRA1, GLRB, SLC6A5

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Metabolic/Mitochondrial Epilepsy (92 Genes, EPI19)

AARS2, ABAT, ABCC8, ACY1, ADK, ADSL, ALDH5A1, ALDH7A1, AMT, ATIC, AUH, BCKDHA, BCKDHB, BCKDK, BCS1L, BTD, CARS2, CNNM2, COQ4, COQ8A, CPT2, D2HGDH, DARS2, DBT, DHFR, DLD, DPYD, EARS2, ETFA, ETFB, ETFDH, ETHE1, FARS2, FH, FOLR1, FOXRED1, GAMT, GATM, GCDH, GCH1, GCK, GCSH, GFM1, GLDC, GLUD1, GLUL, GPHN, HADH, HLCS, HPD, IDH2, ITPA, IVD, KCNJ11, L2HGDH, LIAS, MLYCD, MMACHC, MOCS1, MOCS2, MT-ATP6 (m.8993T>G/C), MT-TK (m.8344A>G), MT-TL1 (m.3243A>G; m.3271T>C), MTHFR, NARS2, NDUFA1, PC, PCBD1, PCCA, PCCB, PDHA1, PDHX, PDSS2, PET100, PHGDH, PNPO, POLG, PSAT1, PSPH, PTS, QDPR, SDHA, SLC16A1, SLC19A3, SLC25A1, SLC2A1, SLC46A1, SLC6A8, SUOX, SURF1, TWNK, VARS2

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Metabolic Diseases

Congenital Disorders of Glycosylation (CDG syndrome) (44 Genes, MET01)

ALG1, ALG11, ALG12, ALG13, ALG2, ALG3, ALG6, ALG8, ALG9, B4GALT1, CAD, CCDC115, COG1, COG2, COG4, COG5, COG6, COG7, COG8, DDOST, DOLK, DPAGT1, DPM1, DPM2, DPM3, MAN1B1, MGAT2, MOGS, MPDU1, MPI, NGLY1, PGM1, PMM2, RFT1, SLC35A1, SLC35A2, SLC35C1, SLC39A8, SRD5A3, SSR4, STT3A, STT3B, TMEM165, TMEM199

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Lysosomal Disorders (37 Genes, MET02)

AGA, ARSA, ARSB, CTNS, CTSA, FUCA1, GALC, GALNS, GBA, GLA, GLB1, GM2A, GNPTAB, GNPTG, GNS, GUSB, HEXA, HEXB, HGSNAT, HYAL1, IDS, IDUA, LIPA, MAN1B1, MAN2B1, MANBA, MCOLN1, NAGA, NAGLU, NEU1, NPC1, NPC2, PSAP, SGSH, SLC17A5, SMPD1, SUMF1

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Peroxisome Biogenesis Disorders: Zellweger Syndrome Spectrum (19 Genes, MET03)

ABCD1, ACOX1, AMACR, HSD17B4, PEX1, PEX10, PEX11B, PEX12, PEX13, PEX14, PEX16, PEX19, PEX2, PEX26, PEX3, PEX5, PEX6, PEX7, SCP2

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Pyridoxine- and Folic Acid-dependent Epilepsy (6 Genes, MET04)

ALDH7A1, DHFR, FOLR1, MTHFR, PNPO, SLC46A1

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Glutaraciduria (4 Genes, MET05)

ETFA, ETFB, ETFDH, GCDH

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Glycine Encephalopathy (3 Genes, MET06)

AMT, GCSH, GLDC

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Hyperphenylalaninemia (5 Genes, MET07)

GCH1, PAH, PCBD1, PTS, QDPR

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Maple Syrup Urine Disease and DLD Deficiency (4 Genes, MET08)

BCKDHA, BCKDHB, DBT, DLD

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Molybdenum Cofactor Deficiency and Sulfite Oxidase Deficiency (4 Genes, MET09)

GPHN, MOCS1, MOCS2, SUOX

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Urea Cycle Disorders and Secondary Hyperammonemia (18 Genes, MET10)

ARG1, ASL, ASS1, CPS1, CPT2, GLUD1, LMBRD1, MMAA, MMAB, MMACHC, MMADHC, MUT, NAGS, OTC, PCCA, PCCB, SLC25A15, SLC7A7

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Glycogen Storage Disease (20 Genes, MET11)

AGL, ALDOA, FBP1, G6PC, GAA, GBE1, GYS1, GYS2, LAMP2, LDHA, PFKM, PGAM2, PHKA1, PHKA2, PHKB, PHKG2, PYGL, PYGM, SLC2A2, SLC37A4

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Hyperinsulinemic Hypoglycemia (7 Genes, MET12)

ABCC8, GCK, GLUD1, HADH, INSR, KCNJ11, SLC16A1

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Methylmalonic Acidemia (6 Genes, MET13)

LMBRD1, MMAA, MMAB, MMACHC, MMADHC, MUT

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Brain Development Disorders

Microcephaly and Pontocerebellar Hypoplasia (64 Genes, BRN01)

AMPD2, ANKLE2, ASNS, ASPM, ATR, BRF1, CASK, CDC6, CDK5RAP2, CDK6, CDT1, CENPE, CENPJ, CEP135, CEP152, CEP63, CHMP1A, CKAP2L, CLP1, DYRK1A, EFTUD2, EXOSC3, EXOSC8, FOXG1, GMNN, IER3IP1, KAT6A, KIF11, KNL1, MBD5, MCPH1, MFSD2A, NIN, ORC1, ORC4, ORC6, PCLO, PHC1, PLK4, PNKP, PPP1R15B, PQBP1, QARS, RARS2, RBBP8, SASS6, SEPSECS, SLC25A19, SMARCA2, SPATA5, STAMBP, STIL, TRAIP, TRMT10A, TSEN2, TSEN34, TSEN54, TUBGCP4, TUBGCP6, VPS53, VRK1, WDR62, WDR73, ZNF335

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Neuronal Migration Disorders (66 Genes, BRN02)

ACTB, ACTG1, ADGRG1, AKT3, ARFGEF2, ARX, B3GALNT2, B3GNT1, CCND2, CDK5, COL4A1, COL4A2, DAG1, DCHS1, DCX, DYNC1H1, EMX2, EOMES, ERMARD, FAT4, FKRP, FKTN, FLNA, GMPPB, IER3IP1, ISPD, KATNB1, KIF1BP, KIF2A, KIF5C, LAMB1, LAMC3, LARGE, MEF2C, MTOR, NDE1, NEDD4L, OCLN, PAFAH1B1, PI4KA, PIK3CA, PIK3R2, POMGNT1, POMGNT2, POMK, POMT1, POMT2, RAB18, RAB3GAP1, RAB3GAP2, RELN, RTTN, SHH, SIX3, TBC1D20, TMEM5, TUBA1A, TUBA8, TUBB, TUBB2A, TUBB2B, TUBB3, TUBG1, VLDLR, WDR62, WDR81

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Holoprosencephaly Spectrum (9 Genes, BRN03)

CDON, FGFR1, GLI2, PTCH1, SHH, SIX3, TDGF1, TGIF1, ZIC2

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Macrocephaly (33 Genes, BRN04)

AKT3, ASPA, BRWD3, CCDC88C, CCND2, CUL4B, DNMT3A, EZH2, GCDH, GFAP, GPC3, HEPACAM, IGF2, KPTN, L1CAM, MED12, MLC1, MTOR, NFIX, NSD1, PHF6, PIGA, PIGN, PIGT, PIK3CA, PIK3R2, PTCH1, PTEN, RIN2, RNF135, SETD2, STRADA, TBC1D7

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Leukodystrophy and Leukoencephalopathy (76 Genes, BRN05)

AARS, AARS2, ABCD1, ACOX1, ADAR, AIMP1, ALDH3A2, ARSA, ASPA, BCAP31, C11orf73, CLCN2, CSF1R, CTC1, CYP27A1, DARS, DARS2, EARS2, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, FAM126A, FUCA1, GALC, GBE1, GCDH, GFAP, GJC2, HEPACAM, HSD17B4, HSPD1, HTRA1, IFIH1, L2HGDH, LMNB1, MLC1, NOTCH3, PEX1, PEX10, PEX11B, PEX12, PEX13, PEX14, PEX16, PEX19, PEX2, PEX26, PEX3, PEX5, PEX6, PEX7, PLEKHG2, PLP1, POLR1C, POLR3A, POLR3B, PSAP, PYCR2, RARS, RNASEH2A, RNASEH2B, RNASEH2C, RNASET2, SAMHD1, SCP2, SLC16A2, SLC17A5, SOX10, SUMF1, TREM2, TREX1, TUBB4A, TYROBP, VPS11

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Aicardi-Goutières Syndrome (7 Genes, BRN06)

ADAR, IFIH1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, TREX1

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Joubert Syndrome / Meckel Syndrome (30 Genes, BRN07)

AHI1, ARL13B, B9D1, B9D2, C5orf42, CC2D2A, CEP104, CEP164, CEP290, CEP41, CSPP1, INPP5E, KIAA0586, KIF7, MKS1, NPHP1, NPHP3, OFD1, PDE6D, RPGRIP1L, TCTN1, TCTN2, TCTN3, TMEM138, TMEM216, TMEM231, TMEM237, TMEM67, TTC21B, ZNF423

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Cornelia de Lange Syndrome (6 Genes, BRN08)

HDAC8, NIPBL, RAD21, SMC1A, SMC3, UBE2A

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Cerebral Microangiopathies (6 Genes, BRN09)

COL4A1, CTC1, GLA, HTRA1, NOTCH3, TREX1

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Leukodystrophy and Leukoencephalopathy and Differential Diagnoses (176 Genes, BRN10)

AARS, AARS2, ABCD1, ACOX1, ADAR, AGA, AIMP1, ALDH3A2, AP4E1, APOPT1, ARSA, ASPA, ATP7A, ATP7B, AUH, BCAP31, BCS1L, C11orf73, C12orf65, CLCN2, COL4A1, COL4A2, COX10, COX15, COX6B1, CSF1R, CTC1, CYP27A1, CYP7B1, D2HGDH, DARS, DARS2, DDHD2, EARS2, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, ERCC2, ERCC3, ERCC6, ERCC8, ETFA, ETFB, ETFDH, FA2H, FAM126A, FARS2, FKRP, FKTN, FOLR1, FOXRED1, FUCA1, GALC, GAN, GBE1, GCDH, GFAP, GFM1, GJC2, GLA, GLB1, GMPPB, HEPACAM, HEXA, HMGCL, HSD17B4, HSPD1, HTRA1, IBA57, IDS, IFIH1, ISCA2, KCNT1, L2HGDH, LAMA2, LARGE, LMNB1, LRPPRC, MCOLN1, MLC1, MMACHC, MPV17, MTFMT, NADK2, NDUFA1, NDUFA12, NDUFA2, NDUFA9, NDUFAF1, NDUFAF2, NDUFAF5, NDUFAF6, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS7, NDUFS8, NDUFV1, NEU1, NOTCH3, NPC1, NPC2, NUBPL, OCLN, OCRL, PC, PET100, PEX1, PEX10, PEX11B, PEX12, PEX13, PEX14, PEX16, PEX19, PEX2, PEX26, PEX3, PEX5, PEX6, PEX7, PHGDH, PHYH, PLA2G6, PLEKHG2, PLP1, POLG, POLR1C, POLR3A, POLR3B, POMGNT1, POMT1, POMT2, PRF1, PSAP, PSAT1, PYCR2, RARS, RNASEH2A, RNASEH2B, RNASEH2C, RNASET2, SAMHD1, SCO2, SCP2, SDHA, SDHAF1, SLC16A2, SLC17A5, SLC25A1, SLC25A12, SOX10, SPG11, SPG20, SPG21, STX11, STXBP2, SUCLA2, SUMF1, SURF1, TACO1, TBCK, TMEM70, TREM2, TREX1, TTC19, TUBB4A, TUFM, TYMP, TYROBP, UNC13D, VPS11, ZFYVE26

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Complete Panel - Epilepsy, Metabolic and Brain Development Disorders (634 Genes)

AARS, AARS2, ABAT, ABCC8, ABCD1, ACOX1, ACTB, ACTG1, ACY1, ADAR, ADGRG1, ADK, ADRA2B, ADSL, AFG3L2, AGA, AGL, AHI1, AIMP1, AKT3, ALDH3A2, ALDH5A1, ALDH7A1, ALDOA, ALG1, ALG11, ALG12, ALG13, ALG2, ALG3, ALG6, ALG8, ALG9, AMACR, AMPD2, AMT, ANKLE2, AP4E1, APOPT1, ARFGEF2, ARG1, ARHGEF9, ARL13B, ARSA, ARSB, ARX, ASAH1, ASL, ASNS, ASPA, ASPM, ASS1, ATIC, ATP13A2, ATP1A2, ATP1A3, ATP7A, ATP7B, ATR, AUH, B3GALNT2, B3GNT1, B4GALT1, B9D1, B9D2, BCAP31, BCKDHA, BCKDHB, BCKDK, BCS1L, BRAT1, BRF1, BRWD3, BTD, C12orf65, C5orf42, CACNA1A, CAD, CARS2, CASK, CC2D2A, CCDC115, CCDC88C, CCND2, CDC6, CDK5, CDK5RAP2, CDK6, CDKL5, CDON, CDT1, CENPE, CENPJ, CEP104, CEP135, CEP152, CEP164, CEP290, CEP41, CEP63, CERS1, CHD2, CHMP1A, CHRNA4, CHRNB2, CKAP2L, CLCN2, CLN3, CLN5, CLN6, CLN8, CLP1, CNNM2, CNTN2, COG1, COG2, COG4, COG5, COG6, COG7, COG8, COL4A1, COL4A2, COQ4, COQ8A, COX10, COX15, COX6B1, CPS1, CPT2, CSF1R, CSPP1, CSTB, CTC1, CTNS, CTSA, CTSD, CTSF, CUL4B, CYP27A1, CYP7B1, D2HGDH, DAG1, DARS, DARS2, DBT, DCHS1, DCX, DDHD2, DDOST, DEPDC5, DHFR, DLD, DNAJC5, DNM1, DNMT3A, DOCK7, DOLK, DPAGT1, DPM1, DPM2, DPM3, DPYD, DYNC1H1, DYRK1A, EARS2, EEF1A2, EFTUD2, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EMX2, EOMES, EPM2A, ERCC2, ERCC3, ERCC6, ERCC8, ERMARD, ETFA, ETFB, ETFDH, ETHE1, EXOSC3, EXOSC8, EZH2, FA2H, FAM126A, FARS2, FAT4, FBP1, FGFR1, FH, FKRP, FKTN, FLNA, FOLR1, FOXG1, FOXRED1, FUCA1, G6PC, GAA, GABRA1, GABRB3, GABRG2, GALC, GALNS, GAMT, GAN, GATM, GBA, GBE1, GCDH, GCH1, GCK, GCSH, GFAP, GFM1, GJC2, GLA, GLB1, GLDC, GLI2, GLRA1, GLRB, GLUD1, GLUL, GM2A, GMNN, GMPPB, GNAO1, GNB1, GNPTAB, GNPTG, GNS, GOSR2, GPC3, GPHN, GRIN1, GRIN2A, GRIN2B, GRIN2D, GRN, GUSB, GYS1, GYS2, HACE1, HADH, HCN1, HDAC8, HEPACAM, HEXA, HEXB, HGSNAT, HIKESHI, HLCS, HMGCL, HNRNPU, HPD, HSD17B4, HSPD1, HTRA1, HYAL1, IBA57, IDH2, IDS, IDUA, IER3IP1, IFIH1, IGF2, INPP5E, INSR, IQSEC2, ISCA2, ISPD, ITPA, IVD, KAT6A, KATNB1, KCNA1, KCNA2, KCNB1, KCNC1, KCNJ11, KCNMA1, KCNQ2, KCNQ3, KCNT1, KCTD7, KIAA0586, KIF11, KIF1BP, KIF2A, KIF5C, KIF7, KNL1, KPTN, L1CAM, L2HGDH, LAMA2, LAMB1, LAMC3, LAMP2, LARGE, LDHA, LGI1, LIAS, LIPA, LMBRD1, LMNB1, LMNB2, LRPPRC, MAN1B1, MAN2B1, MANBA, MBD5, MCOLN1, MCPH1, MECP2, MED12, MEF2C, MFSD2A, MFSD8, MGAT2, MKS1, MLC1, MLYCD, MMAA, MMAB, MMACHC, MMADHC, MOCS1, MOCS2, MOGS, MPDU1, MPI, MPV17, MT-ATP6 (m.8993T>G/C), MT-TK (m.8344A>G), MT-TL1 (m.3243A>G; m.3271T>C), MTFMT, MTHFR, MTOR, MUT, NADK2, NAGA, NAGLU, NAGS, NARS2, NDE1, NDUFA1, NDUFA12, NDUFA2, NDUFA9, NDUFAF1, NDUFAF2, NDUFAF5, NDUFAF6, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS7, NDUFS8, NDUFV1, NECAP1, NEDD4L, NEU1, NFIX, NGLY1, NHLRC1, NIN, NIPBL, NOTCH3, NPC1, NPC2, NPHP1, NPHP3, NPRL2, NPRL3, NSD1, NUBPL, OCLN, OCRL, OFD1, ORC1, ORC4, ORC6, OTC, PAFAH1B1, PAH, PC, PCBD1, PCCA, PCCB, PCDH19, PCLO, PDE6D, PDHA1, PDHX, PDSS2, PET100, PEX1, PEX10, PEX11B, PEX12, PEX13, PEX14, PEX16, PEX19, PEX2, PEX26, PEX3, PEX5, PEX6, PEX7, PFKM, PGAM2, PGAP2, PGAP3, PGM1, PHC1, PHF6, PHGDH, PHKA1, PHKA2, PHKB, PHKG2, PHYH, PI4KA, PIGA, PIGG, PIGL, PIGM, PIGN, PIGO, PIGT, PIGV, PIGW, PIGY, PIK3CA, PIK3R2, PLA2G6, PLCB1, PLEKHG2, PLK4, PLP1, PMM2, PNKP, PNPO, POLG, POLR1C, POLR3A, POLR3B, POMGNT1, POMGNT2, POMK, POMT1, POMT2, PPP1R15B, PPT1, PQBP1, PRDM8, PRF1, PRICKLE1, PRRT2, PSAP, PSAT1, PSPH, PTCH1, PTEN, PTS, PURA, PYCR2, PYGL, PYGM, QARS, QDPR, RAB18, RAB3GAP1, RAB3GAP2, RAD21, RARS, RARS2, RBBP8, RELN, RFT1, RIN2, RNASEH2A, RNASEH2B, RNASEH2C, RNASET2, RNF135, ROGDI, RPGRIP1L, RTTN, SAMHD1, SASS6, SCARB2, SCN1A, SCN1B, SCN2A, SCN8A, SCO2, SCP2, SDHA, SDHAF1, SEPSECS, SERPINI1, SETD2, SGSH, SHH, SIK1, SIX3, SLC12A5, SLC13A5, SLC16A1, SLC16A2, SLC17A5, SLC19A3, SLC1A3, SLC25A1, SLC25A12, SLC25A15, SLC25A19, SLC25A22, SLC2A1, SLC2A2, SLC35A1, SLC35A2, SLC35C1, SLC37A4, SLC39A8, SLC46A1, SLC6A1, SLC6A5, SLC6A8, SLC7A7, SLC9A6, SMARCA2, SMC1A, SMC3, SMPD1, SOX10, SPATA5, SPG11, SPG20, SPG21, SPTAN1, SRD5A3, SSR4, ST3GAL3, ST3GAL5, STAMBP, STIL, STRADA, STT3A, STT3B, STX11, STX1B, STXBP1, STXBP2, SUCLA2, SUMF1, SUOX, SURF1, SYNGAP1, SZT2, TACO1, TBC1D20, TBC1D24, TBC1D7, TBCK, TCF4, TCTN1, TCTN2, TCTN3, TDGF1, TGIF1, TMEM138, TMEM165, TMEM199, TMEM216, TMEM231, TMEM237, TMEM5, TMEM67, TMEM70, TPP1, TRAIP, TREM2, TREX1, TRMT10A, TSC1, TSC2, TSEN2, TSEN34, TSEN54, TTC19, TTC21B, TUBA1A, TUBA8, TUBB, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBG1, TUBGCP4, TUBGCP6, TUFM, TWNK, TYMP, TYROBP, UBE2A, UBE3A, UNC13D, VARS2, VLDLR, VPS11, VPS53, VRK1, WDR45, WDR62, WDR73, WDR81, WWOX, ZEB2, ZFYVE26, ZIC2, ZNF335, ZNF423

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